We describe computational aspects of fingerprinting clone libraries (principally cDNAs), using data from the hybridisation of short oligonucleotide probes onto nylon filters which contain clones arrayed at high density. The topics covered are:

• Selection of probes
• Image analysis of filters
• Assesment of hybridisation quality using control clones
• Matching observed fingerprints of clones with known sequence to their expected fingerprints
• Clustering of cDNA clones

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