Monday, August 8, 2011
6:00 - 8:00pm Reception at Panico's Restaurant
103 Church Street
New Brunswick, NJ
(732)545-6100
Panico's is within walking distance of the Heldrich Hotel.
Here are directions
Tuesday, August 9, 2011
7:45 Poster setup
8:15 - 9:00 Registration and Breakfast
9:00 - 9:30 Conference Overview Lynn Caporale
9:30 - 9:45 Special Guest: Evelyn Witkin
A brief look back
Session I: DNA Sequence, Structure and Replication
Session Chair: Thomas Kunkel
10:00 - 10:30 Balancing eukaryotic replication asymmetry with replication fidelity
Thomas Kunkel, Laboratory of Molecular Genetics and Laboratory of Structural Biology
10:30 - 11:00 DNA sequence context-dependent mutations
Jan Drake, National Institute of Environmental Health Sciences
11:00 - 11:30 Break
11:30 - 12:00 Sequence-context dependence of DNA conformation
Victor Zhurkin, National Cancer Institute, NIH
12:00 - 12:30 Structural Transitions in Superhelically stressed DNA
Craig Benham, University of California at Davis
12:30 - 1:20 Lunch
Session II: Selection for Rapid Generation of Diversity
Session Chair: Richard Moxon
1:20 - 1:30 Welcoming Remarks
Rebecca Wright, DIMACS Deputy Director
1:30 - 2:00 Indirect selection of local mutation rates
David King, Southern Illinois University - Carbondale
2:00 - 2:30 Rapid Generation of Diversity in Bacterial Contingency Genes
Richard Moxon, University of Oxford
2:30 - 3:00 Phenotypic variation due to Tandem Repeats in Mammals
John "Trey" Fondon, University of Texas
3:00 - 3:30 Break
3:30 - 4:00 Determinants of repeat instability and genome evolution
David Mittelman, Virginia Bioinformatics Institute
4:00 - 4:30 Adaptive Evolution via Repeated Deletions in a Vertebrate Enhancer
Kathy Xie, Stanford University School of Medicine
5:00 - 5:30 Exogenes: accelerated evolution of venom peptides from cone snails and other venomous molluscs
Baldomero Olivera, University of Utah
5:30 Poster session and buffet dinner
Wednesday, August 10, 2011
8:30 - 9:00 Breakfast and Registration
Session III: Inducible focused variation
Session Chair: Nancy Maizels
9:00 - 9:30 DNA structure and regulated region-directed recombination
Nancy Maizels, University of Washington
9:30 - 10:00 Balance between error-free and error-prone DNA repair in the immunoglobulin loci
Patricia Gearhart, National Institute on Aging, NIH
10:00 - 10:30 Evolution of active deamination of DNA and RNA
Silvestro Conticello, Core Research Laboratory, Istituto Toscano Tumori, Firenze
10:30 - 11:00 Break
11:00 - 11:30 The mechanisms underlying mutagenesis in E. coli,
the p53 tumor suppressor gene, and somatic hypermutation
Barbara Wright, The University of Montana
11:30 - 12:00 The three dimensional spatial organization of the Igh locus directs class switch recombination
Amy Kenter, University of Illinois College of Medicine, Chicago
12:00 - 12:30 Distribution and Mechanisms of Meiotic Recombination
Liisa Kauppi, Memorial Sloan-Kettering Cancer Center
12:30 - 1:30 Lunch
Session IV: Genetic variation under stress and other signals
Session Chair: Nancy Craig
1:30 - 2:00 Control and function of translesion DNA polymerases
Graham Walker, Massachusetts Institute of Technology
2:00 - 2:30 Environmental Regulation of Switching rates in Phase Variable Pathogens and Commensal Bacteria
Chris Bayliss, University of Leicester
2:30 - 3:00 DNA double-strand-breaks localize stress-induced mutagenesis in the E. coli genome
Susan Rosenberg, Baylor College of Medicine
3:00 - 3:30 Break
3:30 - 4:00 Initiation of stress-induced mutagenesis and nonhomologous recombination through transcriptional RNA/DNA hybrid molecules
Phil Hastings
4:00 - 4:30 Metabolite-dependent alteration of RNA folding, splicing and function
Narasimhan Sudarsan, Yale University
4:30 - 5:00 Knowing where transposons go and why
Nancy Craig, Johns Hopkins University School of Medicine
5:30 Poster Session and Buffet Dinner
Thursday, August 11, 2011
8:30 - 9:00 Breakfast and Registration
Session V: Protocols
Session Chair: Laura Landweber
9:00 - 9:30 Protocols, from the Internet to the Genome
John Doyle, California Institute of Technology
9:30 - 10:00 Integrons: Frameworks for information sharing
Ruth Hall, The University of Sydney
10:00 - 10:30 Materials and methods in the generation of immune diversity in invertebrates
L. Courtney Smith, George Washington University
10:30 - 11:00 Break
11:00 - 11:30 Generation of variation in trypanosomes
David Barry, Wellcome Trust Centre for Molecular Parisitology, Glasgow, Scotland, UK
11:30 - 12:00 RNA-mediated epigenetic inheritance in Oxytricha
Laura Landweber, Princeton University
12:00 - 12:30 Cryptogenes and RNA Editing
Ruslan Aphasizhev, University of California, Irvine
12:30 - 1:30 Lunch
Session VI: Evolution, of Genomes and Tumors
Session Chair: Baldomero Olivera
1:30 - 2:00 Multiple levels of meaning in DNA sequences? and one more
Ed Trifonov, University of Haifa
2:00 - 2:30 Sites of genetic instability in mitosis and cancer
Ann Casper, Eastern Michigan University
2:30 - 3:00 Dissecting homologous recombination outcomes: A critical role for noncrossovers in genomic diversity
Francesca Cole, Memorial Sloan-Kettering Cancer Center
3:00 - 3:30 Break
3:30 - 4:00 Transposable elements in Human Germline Genetic Variation and Cancer
Kathleen H. Burns, Johns Hopkins University School of Medicine
4:00 - 4:30 Genome organization and evolution in vertebrates
Giorgio Bernardi, Rome University
4:30 - 5:00 Cancer, Evolving
Lawrence Loeb, University of Washington
If you would like to contribute a poster, please send title/abstract to Nicole Clark at nicolec at dimacs.rutgers.edu no later than June 1, 2011. You will be notified of acceptance of your poster as soon as possible after you submit it.
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