DIMACS TR: 2002-11

Coronary Risk Prediction by Logical Analysis of Data

Authors: Sorin Alexe, Eugene Blackstone, Peter L. Hammer, Hemant Ishwaran, Michael S. Lauer, Claire E. Pothier Snader


The objective of this study was to distinguish within a population of patients with known or suspected coronary artery disease groups at high and at low mortality rates. The study was based on Cleveland Clinic Foundation's dataset of 9454 patients, of whom 312 died during an observation period of 9 years. The Logical Analysis of Data method was adapted to handle the disproportioned size of the two groups of patients, and the inseparable character of this dataset -- characteristic to many medical problems. As a result of the study, we have identified a high-risk group of patients representing 1/5 of the population, with a mortality rate 4 times higher than the average, and including 3/4 of the patients who died. The low-risk group identified in the study, representing approximately 4/5 of the population, had a mortality rate 3 times lower than the average.

Paper Available at: ftp://dimacs.rutgers.edu/pub/dimacs/TechnicalReports/TechReports/2002/2002-11.ps.gz
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